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Writer's pictureDemian Gitnacht, MD, MPH, FAAFP

Magnesium: A Key Ally for Mental Health and Ketamine Therapy

When it comes to health supplements, magnesium might not get the same buzz as flashy superfoods or trendy adaptogens, but don’t let its understated reputation fool you. This powerhouse mineral is involved in over 300 biochemical reactions in the body, influencing everything from energy production to nerve function. Whether you’re battling stress, trying to improve sleep, or even undergoing ketamine-assisted psychotherapy (KAP), oral magnesium supplements could be a game-changer.


Magnesium plays a crucial role in regulating the nervous system, which makes it particularly relevant for anyone seeking emotional balance or mental clarity. Many studies have linked magnesium deficiency to anxiety, depression, and even poor stress resilience. For individuals undergoing KAP, magnesium’s calming properties can enhance the therapeutic effects of ketamine by supporting neuroplasticity – the brain’s ability to rewire itself. Think of it as fertilizer for your neural garden, helping those new mental connections thrive.


Magnesium doesn’t stop there when it comes to supporting KAP. One of ketamine's most powerful effects in psychotherapy is its ability to promote neuroplasticity – essentially, rewiring the brain for healthier thought patterns and emotional resilience. Magnesium complements this process by activating NMDA receptors, which play a vital role in learning and memory. It also helps reduce the risk of neurotoxicity, creating a safe and fertile environment for new neural pathways to form. Additionally, magnesium is known to help stabilize mood, enhance sleep quality, and lower stress – all of which can bolster the integrative work that follows a KAP session. For those undergoing KAP, magnesium isn’t just a nice-to-have – it’s a powerful ally in maximizing the therapy’s outcomes.


If you’re considering magnesium supplementation, timing and method of intake can enhance its effectiveness. Magnesium supplements can generally be taken in the morning or evening, depending on your personal goals. For instance, if you’re taking magnesium to support energy production or aid in focus, the morning is an excellent time. For those using it to improve sleep quality or relax muscles, taking it in the evening may be more beneficial. Magnesium can be taken with or without food, but pairing it with meals rich in certain nutrients, like vitamin D or calcium, can improve absorption. Foods such as avocado, yogurt, or fatty fish can enhance magnesium uptake, as can avoiding high-phytate foods, like raw spinach or bran, during supplementation, as these can inhibit absorption.


There are various forms of magnesium supplements, each with unique benefits. Magnesium glycinate is the go-to for relaxation and sleep, as it’s easily absorbed and gentle on the stomach. Magnesium citrate, on the other hand, has a mild laxative effect, making it a good choice for those who also struggle with occasional constipation. Magnesium malate is fantastic for energy production, while magnesium threonate stands out for its ability to cross the blood-brain barrier, potentially improving memory and cognitive function. A general recommendation for adults is 310 – 420 mg of elemental magnesium daily, but individual needs may vary. Always consult your healthcare provider to find the best dosage and type for you.


Of course, supplements aren’t the only way to boost your magnesium levels. This mineral is naturally found in many delicious foods. Leafy greens like spinach, nuts and seeds, legumes such as black beans, whole grains, and even dark chocolate are excellent sources. If you’re aiming for a dietary approach, a magnesium-rich meal plan can be a delicious and wholesome addition to your wellness routine.


But magnesium isn’t for everyone. Certain medical conditions, such as kidney disease, can make supplementation unsafe. It’s also worth noting that magnesium may interact with some medications, including certain antibiotics and diuretics. And while more magnesium is generally better for most, overdoing it can lead to digestive upset. Start slow and let your body guide you.


So, should you hop on the magnesium bandwagon? If you’re someone seeking to optimize your mental health, regulate stress, or amplify the benefits of KAP, it’s worth considering. Adding magnesium into your regimen – whether through food or a thoughtfully chosen supplement – can be a simple yet profound way to support your mind and body.


Magnesium might not be a quick fix, but it’s a foundational element that helps your body and brain work better, making it a key ally in mental health and ketamine therapy. So, grab a handful of sunflower seeds to snack on or consider a thoughtfully chosen supplement and let this mighty mineral work its magic. Your brain will thank you.


Assortment of foods high in magnesium

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