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Writer's pictureDemian Gitnacht, MD, MPH, FAAFP

Omega-3 Fatty Acids: Fuel for Your Brain and Beyond

When I was working in a research lab at the University of Reno, we spent hours studying omega-3 fatty acids in nude athymic mice (yes, hairless and adorable in their own unique way). I remember watching the impact these essential fats had on their tiny bodies and thinking, “If omega-3s can do all this for mice, imagine what they can do for us!” Little did I know that years later, I would be talking about the same powerhouse nutrients in the context of mental health and wellness, especially for those undergoing transformative therapies like Ketamine-Assisted Psychotherapy (KAP).


Omega-3 fatty acids are an essential part of a healthy diet, but our bodies cannot produce them on their own, which means they have to come from external sources. They are absorbed through the small intestine and incorporated into cell membranes, where they work their magic. These fatty acids come in three primary forms: ALA, EPA, and DHA. While ALA (alpha-linolenic acid) is found in plant-based foods like flaxseeds and walnuts, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are where the real action happens, particularly when it comes to brain health.


EPA is known for its powerful anti-inflammatory properties. It helps reduce systemic inflammation, which has been linked to a host of chronic conditions, including mental health disorders like depression and anxiety. EPA’s role in reducing inflammation is critical because chronic inflammation can impair neurotransmitter function and make it harder for the brain to regulate mood.


DHA, on the other hand, is like the construction worker of the brain. It makes up a large portion of the brain’s gray matter and the retina in the eyes. DHA is essential for maintaining the structure and function of brain cells. Think of it as the scaffolding that helps keep your neurons strong and resilient. Together, EPA and DHA work synergistically to support optimal brain function, making them crucial for anyone focused on mental health.


Incorporating EPA and DHA into your life does not have to be complicated. They are most commonly found in fatty fish-like salmon, mackerel, sardines, and tuna. For those who do not eat fish, algal oil supplements are an excellent plant-based alternative, as algae are the original source of these nutrients in the marine food chain. You can also find fortified foods like eggs, milk, and yogurt that contain added EPA and DHA. For the supplement route, fish oil capsules or krill oil are widely available and easy to incorporate into your routine. Just be sure to check with your healthcare provider about the right dosage for you, as higher doses may be beneficial for specific needs like managing depression or enhancing cognitive function.


The dosing of omega-3s depends on individual needs, but for most adults, a daily intake of 250-500 mg of combined EPA and DHA is recommended. If you are targeting specific issues like treatment-resistant depression, your provider might recommend a higher dose. Taking these supplements with meals that include healthy fats can improve absorption and ensure your body gets the most benefit.


Now, why are these fats so interesting for mental health, particularly when paired with KAP? Omega-3s do not just help the brain; they fuel it. They promote neuroplasticity, which is the brain’s ability to form new connections – a critical part of the healing process during KAP sessions. They also reduce inflammation, which has been linked to mental health issues like depression and PTSD, and they help stabilize mood and cognitive function. For someone exploring deep emotional terrain in therapy, omega-3s act as a quiet support system, enhancing the brain’s capacity to process and adapt.


Omega-3 fatty acids are like the secret weapon in your wellness arsenal – quietly powerful and always reliable. Back in the lab at the University of Reno, watching those tiny mice benefit from omega-3s, I could see how something so simple could make such a big difference. Now, seeing these same nutrients help people in their mental health journeys, it is even more remarkable. So, whether you are diving into a KAP session, looking to boost your mental clarity, or just aiming to feel a bit better day to day, omega-3s might just be what you need.


At Kalea Wellness, we are dedicated to supporting you at every stage of your wellness journey—whether it's discussing supplementation options or preparing you for transformative KAP therapy. Our goal is to provide the tools and guidance you need to thrive.


foods and supplements containing omega-3 fatty acids

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